Below is some useful information about top-recommended supplements for energy support, including popular products from my dispensary.
The amino acid carnitine, found in high amounts in cardiac and skeletal muscle tissue, is involved in transporting long-chain fatty acids into mitochondria to be used for energy. One form of carnitine, acetyl-l-carnitine (ALCAR), may be better absorbed and has been found to cross the blood-brain barrier. Research suggests that ALCAR supplementation may delay the deterioration of mitochondria and reduce mental and physical fatigue associated with aging.
Top acetyl-l-carnitine supplements on Fullscript:
Acetyl L-Carnitine 800mg by Designs for Health
Acetyl-L-Carnitine by Seeking Health
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Alpha-lipoic acid (ALA), obtained through dietary sources and synthesized in the mitochondria, is an antioxidant and cofactor in mitochondrial energy production. ALA helps to regenerate other antioxidants, including vitamins C, E, and glutathione, the body’s master antioxidant. As a dietary supplement, the antioxidant and anti-inflammatory effects of ALA may benefit individuals with diabetic neuropathy and central nervous system disorders, such as multiple sclerosis and Parkinson’s disease.Top alpha-lipoic acid supplements on Fullscript
Alpha Lipoic Acid 600mg by Pure Encapsulations
Alpha Lipoic Acid (R+) 300mg by Professional Formulas
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The eight B vitamins are essential to brain function and energy production. Deficiency in one or several of these vitamins, such as pyridoxine (B6) and cobalamin (B12), may result in neurological symptoms and cognitive decline. Additionally, thiamin (B1), riboflavin (B2), niacin (B3), and folate (B9) have been studied for their potential to improve symptoms of mitochondrial disorders. In individuals with these conditions, supplementation may reduce fatigue, improve exercise tolerance, and improve general well-being.Top B vitamin supplements on Fullscript
Active B-Complex by Integrative Therapeutics
B-Complex Plus by Pure Encapsulations
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A fat-soluble compound, coenzyme Q10 (CoQ10) is synthesized in the body, found in certain foods, including fish, meat, and whole grains, and commonly used as a supplement. CoQ10 is an antioxidant and a cofactor in the electron transport chain, a critical cycle that occurs in the mitochondria, which supports cellular energy production. Although research findings are mixed, there is some evidence that CoQ10 supplementation may benefit individuals with mitochondrial disorders by increasing muscle strength and improving energy repletion.
Top coenzyme Q10 supplements on Fullscript
UBQH 100mg by Integrative Therapeutics
CoQnol (Ubiquinol) 100mg by Designs for Health
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N-acetyl-cysteine (NAC) is a precursor to the amino acid cysteine and the potent antioxidant glutathione. Preliminary research suggests that NAC supplementation may benefit individuals with chronic fatigue syndrome and protect against degenerative processes, including neurodegenerative diseases and myocardial dysfunction. Further, studies in athletes have shown that NAC may increase athletic performance.
Top n-acetylcysteine supplements on Fullscript
NAC by Integrative Therapeutics
NAC 600mg by Pure Encapsulations
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To learn more, see the Fullscript handouts on Fatigue and Mitochondria.